No, you can use Easy Profile and K2 in the same system. No integration mean that you can't use Easy Profile avatar and profile link in K2 articles or comments (I don't know if there is some integration provided by third-party developer).
Note: to work properly we recommend to disable K2 user profiling from Administration->Components->K2->Parameters->Advanced tab->Enable K2 User Profile. K2 uses a System plugin (instead a User Plugin ) to add fields in registration form, this is a bad way and create compatibility issues with all User Plugins.
We also recommend to try Easy Profile free to understand how it works